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KMID : 0603820080140020097
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Journal of Experimental & Biomedical Science
2008 Volume.14 No. 2 p.97 ~ p.103
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Anti-arthritic Effect of Glucosamine and Oriental Herbal Composition
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Cho Seong-Wan
Kim Young-Il
Lee Young-Jae
Cho Hyoung-Kwon
Kim Young-Kwon
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Abstract
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This study was conducted to investigate the effect of an anti-inflammatory and analgesic action of the glucosamine HCl (Glucosamine) and SH-1 (Glucosamine + Oriental herbal composition combined group). Male sprague-Dawley rats and ICR mice were randomized and these experimental groups were divided into 4 groups. Two control group were given as negative control (saline) and positive control (Ibuprofen, 100 mg/kg) and two groups given as oral administration of Glucosamine (320 m/kg) and SH-1. Carrageenan induced paw edema test, hot plate method, croton oil induced granuloma, capillary permeability test and acetic acid writhing syndrome were also shown to be comparable in the SH-1 group to anti-inflammatory drug group such as positive control group (Ibuprofen). Although further studies should be performed to confirm the effects of SH-1, present results suggest that the combined administration of SH-1 have potential action in anti-inflammatory and analgesic action. It could be applicable for the improvement of arthritic symptoms as a new diet-supplement.
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KEYWORD
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Glucosamine HCl, Arthritis, Anti-inflammatory, Analgesic action
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